基于血液的全基因组DNA甲基化相关性跨体脂和脂肪性相关的生物化学特征
Alesha A Hatton1, Robert F Hillary2, Elena Bernabeu2
1Institute for Molecular Bioscience, Brisbane, Australia.
American journal of human genetics
|August 31, 2023
概括
表观遗传修饰,特别是DNA甲基化 (DNAm),揭示了与肥胖相关的特征之间的强烈相关性. 这种新方法,DNAm相关性,提供了比单独的遗传或表型相关性更深入地了解特征关系.
科学领域:
- 表观遗传学和基因组学
- 人类遗传学 人类遗传学
- 代谢健康 代谢健康
背景情况:
- 全球肥胖率的上升受非遗传因素的影响.
- 像DNA甲基化 (DNAm) 这样的表观遗传修饰对遗传和环境影响敏感.
- 有限的研究存在于跨体脂特征的共享DNA甲基化关联.
研究的目的:
- 介绍和评估DNA甲基化 (DNAm) 相关性,作为一种评估特征之间的共同关联的方法.
- 使用DNAm.探索特征关系超越遗传和表型相关性.
- 调查性别特异性DNAm与身体脂肪特征的关联.
主要方法:
- 利用了来自苏格兰一代的7,519个人的DNAm数据.
- 在OSCA软件中应用了双变量OREML框架来计算DNAm相关性.
- 估计每个特征的性别之间的共享DNAm贡献.
主要成果:
- 在BMI,体脂百分比和腰部至部比率之间确定了强烈的,积极的DNAm相关性 (0.961.00).
- 与遗传和表型相关性相比,观察到更强的DNAm相关性.
- 在BMI的DNAm相关性中检测到显著的性别差异,确定了八个性别特定的DNAm探针.
结论:
- 全基因组的DNAm相关性为与肥胖相关的特征提供了新的见解.
- 这种方法增强了对特征关系的理解,超出了传统的遗传相关性.
- DNAm相关性为探索表观遗传学和复杂特征的相互作用提供了有价值的工具.
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