与抑郁症和减肥相关的周围炎症:一项对低体重患者的纵向研究
Anna P McLaughlin1,2, Ellen Lambert1,2, Rebecca Milton1
1Department of Psychological Medicine, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.
Psychological medicine
|August 31, 2023
概括
抑郁症与减肥患者的炎症增加有关. 这种炎症,而不是抑郁本身,预测手术后体重减轻较差,突出炎症.
科学领域:
- 综合医学是一个整体的医学.
- 肥胖和代谢障碍 肥胖和代谢障碍
- 心理神经免疫学 心理神经免疫学
背景情况:
- 炎症与抑郁症-肥胖周期有关.
- 减肥手术可以改善抑郁症,但手术前的抑郁症可能会阻碍减肥.
- 关于抑郁症,炎症和腹结局的纵向数据很少.
研究的目的:
- 为了研究抑郁症和炎症标志物之间的纵向关联.
- 检查抑郁和炎症对减肥和腹部外科手术后临床结果的影响.
主要方法:
- 在85名减肥手术患者 (41名抑郁症患者,44名对照患者) 的长度观察研究中.
- 通过临床面试评估抑郁症.
- 在手术前和手术后6个月测量血清高灵敏性C反应蛋白 (hsCRP),IL-6 (IL-6) 和IL-10.
主要成果:
- 手术前,抑郁与较高的hsCRP,IL-6和IL-6/10比率相关.
- 手术后,抑郁症患者保持了较高的炎症,尽管体重减轻类似.
- 较高的基线hsCRP预测了较差的体重减轻 (β = -0.28,p = 0.01);基线抑郁症严重程度预测了手术后抑郁症 (β = 0.81,p < 0.001).
结论:
- 抑郁症与独立于肥胖的高度炎症有关.
- 基线炎症,而不是抑郁症,预测手术后6个月减轻体重.
- 炎症可能是减肥患者减肥结果差的主要驱动因素.
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