从1947年到2022年,全球寨卡病毒的分子表征和地理分布
Pirom Noisumdaeng1, Worawat Dangsagul2, Kantima Sangsiriwut3
1Faculty of Public Health, Thammasat University, Pathum Thani, Thailand; Thammasat University Research Unit in Modern Microbiology and Public Health Genomics, Thammasat University, Pathum Thani, Thailand.
概括
寨卡病毒 (ZIKV) 分析揭示了不同的非洲和亚洲血统与特定的亚系. 泰国ZIKV没有出现重组,这表明来自东南亚的独立传播途径.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 流行病学 流行病学
背景情况:
- 寨卡病毒 (ZIKV) 是一个重要的公共卫生问题.
- 了解ZIKV的遗传多样性和地理传播对于疾病控制至关重要.
研究的目的:
- 为了进行ZIKV的分子表征.
- 从1947年到2022年,绘制ZIKV的全球地理分布图.
- 在泰国调查潜在的遗传重组 ZIKV基因组.
主要方法:
- 使用ZIKV编码序列 (CDS) 构建家族遗传树.
- 根据遗传关系和时间表来确定地理分布.
- 使用相似性图和bootscan方法对遗传重组的分析.
主要成果:
- 对717个CDS的遗传学分析确定了两个主要的血统:非洲和亚洲.
- 非洲血统显示了两个亚系;亚洲血统多元化为亚洲和美国亚系.
- 在泰国ZIKV分离物中没有检测到遗传重组.
结论:
- 2006年的泰国ZIKV分离物是已知的第二个最古老的,仅次于1966年的马来西亚原型.
- 有证据表明,ZIKV从东南亚到密克罗尼西亚和法属波利尼西亚有两个独立的传播途径.
- 随后观察到南美国家的扩散.
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