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饮食成分影响高脂肪饮食对成长中的雄性小鼠骨的影响
Laura M Beaver1, Maud Prati2, Kristy E Gilman3
1Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Bone
|August 31, 2023
概括
饮食成分会影响骨健康,即使体重增加也会类似. 与标准的西方饮食相比,修改后的高脂肪饮食与核桃保存了骨微观架构,并减少了小鼠的骨髓脂肪.
科学领域:
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
- 肥胖问题研究研究
背景情况:
- 在动物中,饮食诱导的肥胖模型显示了对骨质的可变影响.
- 了解肥胖性饮食成分对骨健康的影响至关重要.
研究的目的:
- 调查饮食成分是否独立于体重,影响骨健康.
- 为了比较标准的"西方"饮食对骨的影响与含核桃的修改高脂肪饮食.
主要方法:
- 在9周的时间里,小鼠吃了低脂肪,高脂肪"西方"或高脂肪的核桃饮食.
- 用双能X射线吸收计,微计算机断层扫描和组织形态计来评估骨反应.
主要成果:
- 这两种高脂肪饮食都增加了体重增加,但对骨有不同的影响.
- "西方"饮食倾向于减少骨体积和连接性,并增加骨髓脂肪.
- 与"西方"饮食相比,修改后的含有核桃的高脂肪饮食维持了骨微型结构,并减少了骨髓脂肪.
结论:
- 饮食组成在饮食诱导的肥胖模型中显著影响骨健康结果.
- 这些发现挑战了动物肥胖研究对人类饮食模式的可翻译性.
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