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作为一种免疫营养因素,来自人乳的MANF维护了肠道上皮屏障,并防止死性肠球炎

Jie Wang¹, Nan Zhou¹, Peijun Shen²

¹School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

The Journal of nutritional biochemistry

|August 31, 2023

概括

人类母乳含有脑神经细胞衍生的神经营养因子 (MANF),它可以保护早产婴儿免受死角 enterokolitis (NEC). MANF减少炎症并保护肠道屏障,为NEC预防提供潜在的营养干预.

科学领域:

免疫学免疫学免疫学
新生儿医学新生儿医学
胃肠病学胃肠病学

背景情况:

死性肠球炎 (NEC) 是早产婴儿死亡的主要原因之一.
哺乳可以防止NEC,但母乳中的特定保护成分尚未完全理解.
中脑星细胞衍生神经变因子 (MANF) 是一种分泌的蛋白质,具有潜在的免疫调节功能.

研究的目的:

调查人乳中MANF的存在和度.
评估MANF在保护肠道上皮屏障中的免疫调节功能.
探索MANF作为NEC的营养干预措施的潜力.

主要方法:

在母乳 (母乳和成熟牛奶) 和婴儿配方奶粉中量化MANF.
从NEC组织和骨髓衍生的巨细胞 (BMDMs) 中的肠道巨细胞中MANF表达的分析.
评估MANF对促炎性巨细胞,亡以及NF-κB通路的影响.

主要成果:

人类母乳中含有MANF,但婴儿配方奶粉中不存在,乳酪中的度更高.
MANF在肠道巨细胞中表达,并减少了亲炎性巨细胞的炎症和亡.
MANF通过降低巨细胞NF-κB通路的调节来保护肠道上皮细胞和紧密的结节.

结论:

人类母乳衍生的MANF通过调节巨细胞活动,在保护肠道上皮屏障方面发挥着至关重要的作用.
MANF有助于降低肠道炎症和维持上皮质平衡,这解释了母乳养对NEC的保护作用的一部分.
这些发现支持开发基于MANF的营养策略,以预防早产婴儿的NEC.

关键词:

介脑星细胞衍生的神经营养因子.死性肠道结肠炎 (NECO) 是一种来自骨髓的巨细胞.人类牛奶是人类的牛奶.肠道上皮质屏障肠道上皮质屏障过早出生的婴儿早产.

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