基于碳水化合物聚合物的表面改性纳米输送系统,用于增强对结肠癌的目标输送 - - 综述
Ibrahim Abdel Aziz Ibrahim1, Abdullah R Alzahrani1, Ibrahim M Alanazi1
1Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
International journal of biological macromolecules
|August 31, 2023
概括
用碳水化合物聚合物对纳米颗粒表面进行修改,可提高结肠癌治疗的向输送. 这些先进的纳米输送系统显示出更好的抗癌疗效和受控的药物释放.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 碳水化合物聚合物为药物输送提供生物相容性和生物降解性.
- 对于结肠癌,现有的纳米输送系统在药物向方面存在局限性.
- 纳米颗粒的表面修饰是一种提高药物输送的策略.
研究的目的:
- 研究基于碳水化合物聚合物的表面改性纳米输送系统对结肠癌的潜力.
- 提高药物在结直肠癌中的向性输送和抗癌疗效.
主要方法:
- 使用碳水化合物聚合物的纳米颗粒的表面修饰,如奇托,pectin,alginate和 guar gum.
- 用酸和维生素E装饰的PLGA纳米颗粒的开发.
- 制造具有基托桑结合的葡萄糖酸涂层的酸纳米颗粒,装有capecitabine.
主要成果:
- 表面修饰的纳米颗粒显示了增强的目标达到能力和抗癌效果.
- 素装饰的纳米颗粒显示长期释放和更高的抗癌疗效.
- 素结合纳米颗粒表现出pH响应的受控释放和改善的抗癌作用.
结论:
- 表面修饰的碳水化合物聚合物显示出改善结肠癌向输送的显著前景.
- 像pH响应,粘膜粘合和受控释放等属性可以增强治疗策略.
- 这些进展有助于开发更有效,更有针对性的结肠癌治疗方法.
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