早期接触会改变心脏发育,并影响长期心脏功能
Qian Liu1, Cheng Xu1, Jing Jin2
1State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Center for Global Health, Nanjing Medical University, Nanjing, China.
The Science of the total environment
|August 31, 2023
概括
早期的暴露会损害胎儿心脏的发育和功能. 这增加了对成人心脏问题的易感性,即使暴露结束后,突出显著的心脏风险.
科学领域:
- 环境健康 环境健康
- 心血管生物学 心血管生物学
- 发育毒理学 发展毒理学
背景情况:
- (Pb) 是一种无处不在的环境毒素,已知对健康有不良影响.
- 早期接触是令人担忧的,但其对胎儿心脏发育和长期心脏健康的影响尚不清楚.
研究的目的:
- 研究早期暴露对胎儿心脏发育的影响.
- 评估长期的心脏结果和成年后对二次侮辱的易感性.
主要方法:
- 怀孕的小鼠从怀孕1.5天开始接触酸三水合物,直到后代断奶.
- 后代经历了"第二次击中"模式,在4周大时注入 ангиотензин II.
- 通过心声学,组织学,超结构检查和线粒体功能测试来评估心脏功能.
主要成果:
- 早期暴露于会导致心脏异常,包括排泄率降低,心室体积增加,心肌细胞形和线粒体功能障碍.
- 暴露于的后代表现出对 ангиотензин II 诱导的心脏缩,纤维化,亡和心力衰竭的敏感性增加.
- 在暴露于的心脏中观察到关键的sarcomeric和线粒体基因的表达减少.
结论:
- 生命早期低剂量暴露显著影响心脏发育和功能.
- 暴露于会加剧心脏病理反应的第二次侮辱在成年期.
- 提供了对心脏有毒性的证据,并为早期暴露的风险评估提供了信息.
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