免疫代谢在喘的发病过程中的作用
Ziwen Qin1, Yujuan Chen2, Yue Wang1
1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Immunology
|August 31, 2023
概括
喘包括由免疫细胞驱动的慢性呼吸道炎症. 了解免疫代谢,即免疫反应与细胞代谢之间的联系,为这种呼吸系统疾病提供了新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞的新陈代谢
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管喘是一种复杂的呼吸系统疾病,其特点是慢性呼吸道炎症.
- 免疫细胞,如乙氨基基细胞,巨细胞和T淋巴细胞在喘病变发生过程中起着关键作用.
- 在喘中的过敏免疫反应中,特定的分子机制,特别是免疫代谢,尚未完全理解.
研究的目的:
- 审查当前关于在喘发病过程中免疫代谢重编程的知识.
- 探索细胞代谢改变在喘期间免疫细胞功能中的作用.
- 确定潜在的新型治疗策略,针对喘中的免疫代谢.
主要方法:
- 本综述综合了有关喘和免疫代谢现有研究的发现.
- 它检查了与喘相关的免疫细胞中氧化应激和代谢变化 (糖解,脂肪酸,氨基酸) 的研究.
- 该评论分析了参与免疫代谢的信号通路.
主要成果:
- 增强的氧化应激和异常的代谢途径 (糖解,脂肪酸,氨基酸) 在喘中的免疫细胞中被观察到.
- 这些代谢变化导致了喘中先天性和适应性免疫反应的失调.
- 免疫代谢涉及多个信号通路,这些通路都与喘发育有关.
结论:
- 免疫代谢重编程是喘发病的一个重要因素.
- 免疫细胞中细胞代谢的改变有助于呼吸道炎症和反应过敏.
- 向免疫代谢途径为喘治疗提供了有前途的治疗途径.
相关概念视频
Asthma: Pathogenesis and Management
442
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
442
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
342
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
342
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Drugs Used in Lower Respiratory Disorders: Overview
487
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
487
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K


