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Updated: Jul 17, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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通过自基因组固的奇梅拉来向降解α-synuclein

Yichen Tong1, Wentao Zhu1, Jian Chen1

  • 1School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.

Journal of medicinal chemistry
|August 31, 2023
PubMed
概括

研究人员开发了自酶定嵌合体 (ATACC) 来通过自酶解体路径 (ALP) 降解α-synuclein (αSyn). 这种新的向蛋白质降解 (TPD) 工具在治疗神经退行性疾病 (如同核蛋白病变) 中表现有前途.

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Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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