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血管年龄的功能和形态估计的比较

Martin Sigl^1,2, Laura Winter^1,2, Gerhard Schumacher³

¹Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

In vivo (Athens, Greece)

|August 31, 2023

概括

血管年龄 (VA) 估计方法,动脉内膜介质厚度 (CIMT) 和脉冲波分析 (PWA) 产生了不可比较且往往矛盾的结果. 标准化对于可靠的心血管风险评估至关重要.

科学领域:

心血管医学心血管医学
预防性心脏病学预防性心脏病学
生物医学工程生物医学工程

背景情况:

血管年龄 (VA) 是预防性心血管 (CV) 医学的新兴指标.
可以使用形态参数 (例如,动脉内膜介质厚度,CIMT) 或功能参数 (例如,脉冲波分析,PWA) 来估计VA.
PWA是一种庆祝其100周年纪念的技术.

研究的目的:

调查从形态 (CIMT) 和功能 (PWA) 参数中得出的血管年龄 (VA) 的可比性.
在一组志愿者中评估VA估计方法的一致性.

主要方法:

100名志愿者通过高分辨率超声波进行了双边CIMT评估.
在手臂前臂部部位进行了振荡计PWA.
用CIMT和PWA的既定方程计算了血管年龄.

主要成果:

中位数PWA衍生的VA为55.3年,而CIMT衍生的VA差异很大 (中位数为43.7至64.0年).
46%的参与者在两种方法之间显示出不同的VA.
这两种VA测量都与时间年龄和心血管风险因素有很强的相关性.

结论:

目前用于估计血管年龄 (VA) 的方法无法直接比较.
在CIMT和PWA衍生的VA之间经常观察到不同的和矛盾的结果.
临床有效性需要对VA估计方法进行批判性评估和标准化.

关键词:

血管年龄血管年龄动脉硬性动脉硬性冠状动脉超声波冠状动脉超声波亲密介质的厚度.脉冲波分析是一种脉冲波分析.

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