L1CAM不是早期状细胞宫癌的预测因素
Martina Romanová1, Vladimír Židlík2, Veronika Javůrková1
1Department of Obstetrics and Gynecology, Gynecological Oncology Centre, University Hospital Ostrava, Ostrava Poruba, Czech Republic.
In vivo (Athens, Greece)
|August 31, 2023
概括
在早期的宫癌中,L1细胞粘附分子 (L1CAM) 表达并不是负面的预后因素. L1CAM仅与较大的瘤大小相关,而不是生存结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 作为各种癌症的潜在预后标记物,L1细胞粘附分子 (L1CAM) 已被研究.
- 以前的研究表明L1CAM表达是宫癌的负预后因素.
研究的目的:
- 评估L1CAM表达在早期宫平细胞癌的预后意义.
- 确定L1CAM表达是否与疾病复发,存活率或其他组织病理特征相关.
主要方法:
- 在2007年至2017年间对154名患有早期宫平细胞癌的患者进行了回顾性分析.
- 免疫组织化学被用来评估瘤样本中的L1CAM表达.
- L1CAM状态与瘤等级,淋巴血管入侵,瘤大小,结节透,无病间隔和整体存活率的相关性.
主要成果:
- 在15.6%的瘤中观察到L1CAM表达.
- 在L1CAM表达和瘤等级或淋巴血管入侵之间没有发现显著的关联.
- L1CAM表达没有显著影响无病间隔或整体存活率.
- 阳性L1CAM病例的中位瘤大小显著增加 (p=0.015).
- 在没有结节透的患者中,L1CAM状态没有影响复发率.
结论:
- 这项研究没有证实L1CAM是早期宫平细胞癌的负预后因素.
- L1CAM表达与关于复发或生存的不良预后无关.
- 发现L1CAM表达仅与瘤大小增加相关.
相关概念视频
03:18Non-LTR Retrotransposons
11.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.6K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K