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精确瘤学的实用性使用癌症基因组分析来治疗头部和部恶性瘤

Mioko Matsuo¹, Kazuki Hashimoto², Ryunosuke Kogo²

¹Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan matsuo.mioko.202@m.kyushu-u.ac.jp.

In vivo (Athens, Greece)

|August 31, 2023

概括

癌症基因组分析 (CGP) 在大多数头癌患者中发现了可操作的突变. 虽然CGP提供治疗选择,但瘤学家必须核实最佳患者结果的建议.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
精准医学是一门精准的医学.

背景情况:

个体患者癌症基因组分析 (CGP) 越来越多地可用于指导癌症治疗.
精确瘤学,使用CGP来定制治疗,是一种新兴但实验性的方法.
在头恶性瘤中CGP的临床实用性需要进一步研究.

研究的目的:

评估使用CGP指导治疗恶性头和部瘤的可行性和益处.
评估接受CGP的头恶性瘤患者的基因组分析和临床结果.
确定CGP在多大程度上导致了在头癌中有益的药物管理.

主要方法:

对27名头恶性瘤患者的CGP结果,预后和药物管理的分析.
包括完成标准治疗,预计将完成标准治疗或缺乏标准治疗选择的罕见癌症的患者.

主要成果:

在92.6%的患者中发现了可操作的基因变化,平均每患者4个变化.
虽然81.5%的患者在临床试验中被推服用药物,但没有人能够参与.
根据CGP的发现,11.1%的患者接受了未经批准的非标签药物.
TP53突变是最常见的异常 (66.7%) 并与预后不佳相关.

结论:

在临床上,CGP对于扩大头癌的治疗选择具有价值.
基于CGP推的药物可能并不总是有效的.
瘤学家必须严格核实CGP的建议,以确保最佳的患者治疗.

关键词:

癌症基因组分析癌症基因组分析这种突变是TP53突变.头部和部的恶性瘤.免疫检查点抑制剂免疫检查点抑制剂精确瘤学精确瘤学

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