相关实验视频

Updated: Jul 17, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

结肠腺瘤路径的性别差异和结肠直肠癌发生

Yonghoon Choi¹, Nayoung Kim^1,2

¹Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

The world journal of men's health

|August 31, 2023

概括

结肠直肠癌 (CRC) 的发展和结果因性别而异,受生物和行为因素的影响. 了解这些性别差异对于量身定制的查,治疗和预防策略至关重要.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
遗传学遗传学是一个
内分泌学在内分泌学.

背景情况:

结肠直肠癌 (CRC) 在发病率,复发率和存活率方面表现出明显的性别特异性差异.
男性比女性更频繁,更早地发展CRC,这表明雌激素的保护作用.
女性对右侧CRC的倾向更高,这在临床上比左侧CRC更具侵略性.

研究的目的:

审查和综合有关结直肠癌 (CRC) 性别/性别差异的当前知识.
探索受性别和性别影响的CRC致癌的临床病理学,生物学,分子和社会文化方面.
突出了解这些差异对于改善CRC管理的重要性.

主要方法:

文献综述综合了CRC中关于性别/性别差异的现有研究.
对CRC发病率和性别结果的流行病学数据的分析.
检查生物机制,包括荷尔蒙和遗传因素.
考虑对CRC风险和进展的社会文化和行为影响.

主要成果:

根据瘤的位置和性别,CRC致癌途径有所不同,左侧和右侧瘤的分子机制不同.
性二态 (荷尔蒙,遗传) 和性别差异 (行为,社会) 有助于CRC风险和呈现.
雌激素似乎对女性的CRC发展起着保护作用.
饮食,吸烟和体育活动等行为因素有助于基于性别的风险差异.

结论:

性别和性别显著影响结肠直肠癌 (CRC) 的发展,进展和结果.
根据性别/性别差异量身定制查,治疗和预防策略,可以改善患者的生存率和生活质量.
对生物和社会文化因素的相互作用进行进一步的研究对于个性化CRC管理至关重要.

关键词:

结直肠瘤是什么意思早期发现癌症的早期发现主要预防主要预防.性爱性的性爱性的性爱治疗方法治疗方法

更多相关视频

In vitro Organoid Culture of Primary Mouse Colon Tumors

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...