住院患者的长期COVID自主综合征:为期一年的前性队列研究
Stefano Rigo1, Franca Barbic2, Kareem Khalaf3
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
European journal of internal medicine
|August 31, 2023
概括
长期COVID综合征可能导致持续的自主功能障碍. 感染后6个月和12个月出现了意想不到的症状恶化,这表明需要早期干预.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID综合征呈现出各种症状,包括疲劳,认知困难和自主功能障碍.
- 自主神经系统异常越来越多地被认为是潜在的机制,是长期COVID症状的基础.
- 了解这些症状的长期发展轨迹对于有效的患者管理至关重要.
研究的目的:
- 评估SARS-CoV-2感染后自主性症状和生活质量 (QoL) 的短期和长期过程,长达一年.
- 在感染后6个月和12个月,识别患有自主症状恶化的患者.
- 为了区分治愈后COVID患者和患有长COVID自主综合征的患者.
主要方法:
- 一项前性队列研究对112名SARS-CoV-2阳性患者进行了12个月的跟踪.
- 使用复合自主症状尺度31 (COMPASS-31) 评估自主症状.
- 在多个时间点 (PRE,T0,T1,T3,T6,T12) 使用简单形式健康调查 (SF-36) 评估生活质量 (QoL).
主要成果:
- 自主症状和QOL最初从医院出院 (T0) 改善到3个月 (T3).
- 在6个月 (T6) 和12个月 (T12) 观察到自主症状和QoL显著和意想不到的恶化.
- 47%的患者在T6和T12表现出自主症状恶化,定义了长期COVID自主综合征.
结论:
- 长期COVID自主综合征可以在初步改善后表现为症状的延迟恶化.
- 建议在感染后1个月和3个月进行早期康复和药物治疗.
- 在早期康复阶段进行干预可以减轻患慢性自主功能障碍的风险.
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