阿斯巴甜所产生的学习和记忆缺陷是通过父系遗传的
Sara K Jones1, Deirdre M McCarthy1,2, Gregg D Stanwood1,2,3
1Biomedical Sciences, Florida State University College of Medicine, 1115, West Call Street, Tallahassee, FL, 32306, USA.
Scientific reports
|August 31, 2023
概括
每天摄入阿斯巴甜 (一种人工甜味剂) 会导致小鼠的认知缺陷. 这些影响是遗传的,通过父系影响后代,突出显示了直接暴露之外的风险.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 遗传学 遗传学 是一个
背景情况:
- 环境暴露会导致影响后代的遗传性状.
- 人工甜味剂,如阿斯巴甜,被广泛消费,但它们的遗传效应未被评估.
- 监管安全评估通常不考虑遗传影响.
研究的目的:
- 调查阿斯巴甜的消费对潜在的遗传性认知影响.
- 为了确定成年小鼠接触阿斯巴甜是否会影响后代的学习和记忆.
- 评估父亲血统在阿斯巴甜诱导认知缺陷的传播中的作用.
主要方法:
- 小鼠每天摄入阿斯巴甜,长达16周,剂量为FDA最大摄入量的7-15%.
- 在暴露的小鼠及其雄性和雌性后代中评估了空间学习和记忆.
- 认知功能被评估跨代,专注于父亲的血统传输.
主要成果:
- 在小鼠中,阿斯巴甜的消费导致了显著的空间学习和记忆缺陷.
- 这些认知缺陷通过父系传播给男性和女性后代.
- 观察到遗传性认知效应,超出了直接暴露的个体.
结论:
- 阿斯巴甜的消费对认知功能构成风险,可以通过父系继承.
- 男性的环境暴露可能会对后代的认知健康产生不利影响.
- 人工甜味剂的监管评估应包括通过父系遗传效应的评估.
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