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蛋白质工程和代的多模块优化用于大肠杆菌中维生素B6的生产

Linxia Liu1,2,3, Jinlong Li1,3,4, Yuanming Gai1,2

  • 1Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

Nature communications
|August 31, 2023
PubMed
概括

研究人员通过微生物发酵对大肠杆菌进行了改造,使其通过微生物发酵产生一种维生素B6的形式 - - 氧 (PN). 这种可持续的方法实现了高产量,为化学合成提供了替代必需营养素.

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Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
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