人类牛奶的寡糖调节了健康成年人的肠道微生物群
Jonathan P Jacobs1,2,3, Martin L Lee4,5, David J Rechtman5
1The Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. JJacobs@mednet.ucla.edu.
Scientific reports
|August 31, 2023
概括
复杂的人类牛奶寡糖 (HMO) 显著改变了成人肠道微生物群,促进了Bifidobacterium,改变了微生物的组成和功能. 这些影响在HMO停止后仍然存在,突出显示HMO.
科学领域:
- 微生物学和免疫学
- 人类微生物组研究研究
- 营养科学 营养科学
背景情况:
- 人类母乳寡糖化物 (HMO) 对婴儿肠道微生物组的发展至关重要.
- 复杂的HMO混合物对成年肠道微生物群的影响在很大程度上仍未被探索.
研究的目的:
- 研究一种复杂的母乳寡糖化合物 (HMO) 混合物对成年肠道微生物组的影响.
- 确定HMO是否可以调节成年肠道微生物群的组成,功能和宿主免疫标志物.
主要方法:
- 在7天内,口服HMO缩剂给32名健康成年人.
- 使用16S rRNA基因测序,射门甲基因组学和代谢学分析便样本.
- 在服用后28天内监测微生物和血清代谢物变化.
主要成果:
- 诱导HMO缩剂剂量依赖Bifidobacterium扩张和减少微生物多样性.
- 微生物继承,包括Bacteroides扩张,在HMO停止后持续存在.
- 观察到微生物基因含量变化,血清代谢物和循环TGFβ和IL-10的增加.
结论:
- 复杂的HMO混合物直接影响成年肠道微生物群.
- 聚合捐赠奶中的低丰度HMO可能是最大效果的关键.
- HMO调节成人肠道微生物群的组成,功能和宿主免疫反应.
相关概念视频
Anatomy of the Intestines
72.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.4K
What is Monogastric Digestion?
71.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.5K
Bacterial Flora of the Large Intestine
508
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
508


