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随行血压作为长期功能下降的风险因素在一般人群:一个分布式回归方法
Bjørn O Eriksen1,2, Matteo Fasiolo3, Ulla D Mathisen4,5
1Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway. bjorn.odvar.eriksen@unn.no.
Scientific reports
|August 31, 2023
概括
长期高血压 (BP) 可能对一般人群的功能 (GFR) 产生负面影响. 先进的统计模型显示,24小时的 ambulatory BP 的升高与 GFR 在 11 年内的下降有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 随机对照试验对血压 (BP) 对功能 (球粒过率,GFR) 的长期影响提供了有限的洞察力.
- 之前的研究受到短时间的随访和不准确的BP和GFR测量所阻碍.
- 长期随机试验是不可行的,需要替代的调查方法.
研究的目的:
- 为了研究24小时门诊血压 (ABP) 与长期测量的GFR之间的关联.
- 评估BP对功能在没有先前存在病或糖尿病的一般人群队列中的长期影响.
主要方法:
- 一个队列研究设计是使用脏IOhexol清除调查 (RENIS) 队列.
- 参与者 (年龄在50-62岁之间) 来自挪威特罗姆索的普通人口,没有基线心血管疾病,糖尿病或脏疾病.
- 在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量了24小时的血压,在基线测量中测量了24小时的血压,在基线测量中测量了24小时的血压,在基线测量中测量了24小时的血压,在基线测量中测量了24小时的血压,在基线测量中测量了24小时的血压,在基线测量中测量了24小时的血压.
主要成果:
- 传统的回归模型显示,基线ABP或办公室BP与GFR变化率之间没有关联.
- 然而,分布式回归模型 (GAMLSS) 显示,较高的白天心缩,心缩和平均动脉血压与向较低GFR转移有关.
- 升高的血压还与随访期间GFR降至60毫升/分钟/1.73平方米以下的概率增加相关.
结论:
- 对暴露 (ABP) 和结果 (GFR) 的精确测量对于检测微妙的关联至关重要.
- 这项研究强调,在普通人群中,在11年内,更高的门诊血压和功能下降之间存在不利的关联.
- 像GAMLSS这样的先进的统计方法对于在传统模型失败时发现这些长期影响至关重要.
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