在6项临床试验中对多发性硬化症进展的纵向脑成像测量进行全基因组研究
Stephanie J Loomis1, Nilanjana Sadhu2, Elizabeth Fisher2
1Biogen, Cambridge, MA, USA. stephanie.loomis@biogen.com.
Scientific reports
|August 31, 2023
概括
研究人员发现了影响多发性硬化症 (MS) 进展的新遗传因素,与MS风险基因不同. 这些在PTPRD和NEDD4L基因中的发现为MS的药物发现提供了新的目标.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 多发性硬化症 (MS) 进展的遗传基础,特别是在纵向脑MRI指标上,仍然在很大程度上未被探索.
- 了解疾病进展的遗传决定因素对于开发向疗法至关重要.
结论:
- 这项研究确定了与MS进展相关的新型遗传决定因素,PTPRD和NEDD4L,与已知的MS风险遗传学不同.
- 这些发现强调了专注于疾病进展的基因分析的重要性,并为MS药物发现提供了潜在的新途径.
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