[基于老年营养风险指数的非小细胞肺癌老年患者的预后模型]
Xiaonan Zhang1, Yajun Xiong1, Aiguo Xu1
1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhongguo fei ai za zhi = Chinese journal of lung cancer
|August 31, 2023
概括
高老年营养风险指数 (GNRI) 评分表明老年非小细胞肺癌 (NSCLC) 患者的生存率更好. 一个新的Nomogram工具有助于预测生存率,指导及时的营养支持.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 营养状况对于癌症患者的预后至关重要.
- 老年营养风险指数 (GNRI) 是一个潜在的预后指标.
- 患有非小细胞肺癌 (NSCLC) 的老年患者需要进行特定的预后评估.
研究的目的:
- 为了评估GNRI在老年NSCLC患者的预后价值.
- 开发一个Nomogram来预测这个群体的生存率.
主要方法:
- 对65岁以上NSCLC患者的回顾性分析.
- ROC曲线分析以确定最佳的GNRI切线.
- 卡普兰-梅尔和考克斯回归用于生存分析.
- 使用R软件构建和验证名图.
主要成果:
- 高GNRI得分与明显更好的整体存活率 (OS) 相关联.
- GNRI>97.09是一个保护因素 (HR=0.52).
- 升高的CYFRA21-1和晚期 (IV) 是死亡的独立风险因素.
- 诺莫格拉姆显示,对OS的预测准确度很好 (C指数=0.70).
结论:
- 较高的GNRI与老年NSCLC患者的生存率改善有关.
- GNRI截止值可以指导营养干预时间.
- 开发的Nomogram是预测老年NSCLC患者存活率的实用工具.
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