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除了艾滋病毒感染和基于整合酶抑制剂的疗法对口腔细菌组的影响之外

Pablo Villoslada-Blanco¹, Patricia Pérez-Matute², Emma Recio-Fernández¹

¹Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR), C/Piqueras 98, CIBIR Building, Third Floor, 26006, Logroño, La Rioja, Spain.

Scientific reports

|August 31, 2023

概括

人类免疫缺陷病毒 (HIV) 感染和整合酶链转移抑制剂 (INSTIs) 治疗对口腔微生物群产生微妙影响. 虽然存在一些细菌差异,但与对照人群相比,INSTI治疗的HIV患者的整体多样性保持不变.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

口腔微生物群,仅次于肠道微生物群,对健康至关重要.
人类免疫缺陷病毒 (HIV) 感染可能导致口腔功能失调,影响患者的生活质量.
抗逆转录病毒疗法 (ART),包括整合酶链转移抑制剂 (INSTIs),可能会改变口服细菌的组成.

研究的目的:

研究艾滋病毒感染和INSTIs对唾液细菌组合的影响.
分析吸烟等因素对艾滋病毒感染个体口腔微生物群的影响.
评估与艾滋病毒状况和治疗有关的酶水平的变化.

主要方法:

招募26名非艾滋病毒志愿者和30名艾滋病毒感染患者 (15名天真患者,15名在INSTI).
收集唾液样本用于测量酶水平.
使用16S rRNA基因测序分析口腔细菌组合的分析.

主要成果:

未感染艾滋病毒的患者表现出比对照组和INSTIs治疗的患者更高的酶水平.
在各组之间没有检测到口腔细菌组的α或β多样性的显著差异.
特定的细菌类 (例如,Acholeplasmatales) 和属在感染艾滋病毒的群体中表现出改变的丰度,部分独立于吸烟.

结论:

艾滋病毒感染和INSTIs对口腔细菌群多样性的影响有限.
在感染HIV的个体中观察到特定细菌种群的变化,不论是INSTIs.
在原始的艾滋病毒患者中,溶酶水平升高,这表明了炎症反应.

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