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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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哺乳动物CCR4-NOT对翻译核糖体的特定识别和无处不在

Eva Absmeier1,2, Viswanathan Chandrasekaran3, Francis J O'Reilly4

  • 1MRC Laboratory of Molecular Biology (LMB), Cambridge, UK.

Nature structural & molecular biology
|August 31, 2023
PubMed
概括

哺乳动物的CCR4-NOT死化复合体识别了停滞的核糖体,插入CNOT3来阻止翻译. 这种复合体还通过 CNOT4 无所不在的延伸信号停止翻译延伸,链接翻译和mRNA衰变.

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