在一项跨国研究中估计骨质疏松性骨折的经济负担:现实世界的数据视角
A Moayyeri1, J Warden1, S Han2
1UCB Pharma, Slough, UK.
概括
骨质疏松性骨折 (OF) 在澳大利亚,德国,韩国,西班牙和美国的50岁以上女性中造成了显著的医疗费用. 这项研究突出了OF对药房,住院和紧急护理的经济负担.
科学领域:
- 卫生经济学 卫生经济学
- 老年医学 老年医学
- 公共卫生 公共卫生
背景情况:
- 骨质疏松性骨折 (OF) 是一个重要的全球健康问题,特别是在老年人群中.
- 对OF的经济评估对于医疗保健政策和资源分配至关重要.
- 国际OF成本比较往往受到不同的方法的限制.
研究的目的:
- 估计50岁以上女性骨质疏松性骨折 (OF) 的经济负担.
- 在澳大利亚,德国,韩国,西班牙和美国的各种医疗保健系统中使用标准化的方法.
- 提供与OF相关的直接医疗保健成本的公平评估.
主要方法:
- 采用了一个跨国,追溯匹配的队列研究设计.
- 倾向性得分匹配用于将新发现的OF患者与没有OF的对照队列进行比较.
- 在每个国家,在长达5年的随访期间,分析了医疗保健资源利用率和直接医疗成本.
主要成果:
- 在所有研究国家中,OF队列与非OF队列相比,具有显著更高的住院率和更长的住院时间.
- 在每个国家的OF和非OF队列之间观察到总医疗保健成本的实质性和统计学上显著的差异.
- 药房,住院,急诊和门诊护理的调整后成本比率在OF患者中始终较高.
结论:
- 骨质疏松性骨折给全球医疗保健系统带来了相当大的经济负担,正如这项跨国研究所证明的那样.
- 调查结果强调需要有效的卫生政策和干预措施,以减轻OF的财务影响.
- 这项研究为利益相关者和政策制定者提供了有价值的数据,以解决骨质疏松性骨折的经济后果.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
2.4K
相关概念视频
Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Fractures: Bone Repair
3.3K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.3K
Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Study Designs in Epidemiology
264
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
264
Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K
