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相关概念视频

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

864
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
864

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相关实验视频

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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神经刺激性测试和毒性:一个病例控制研究.

Chung-Yao Chien1, Jung-Der Wang2,3, Chou-Ching Lin4,5

  • 1Department of Neurology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704, Taiwan.

Journal of occupational medicine and toxicology (London, England)
|August 31, 2023
PubMed
概括

神经刺激性测试 (NETs) 显示出早期发现神经病变的前景. 与传统方法不同,NET与血液中的含量更好地相关,因为它揭示了因暴露而导致的神经过极化.

关键词:
中央导电时间 导电时间内向整形通道的内向整形通道中毒导致的情况.神经刺激性测试 神经刺激性测试跨的磁刺激和运动导电.

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科学领域:

  • 神经毒理学 神经毒理学
  • 电子生理学 电子生理学
  • 职业健康 职业健康 职业健康

背景情况:

  • 在监测神经病变时,传统的电生理学参数与血液中水平 (BLL) 的相关性较弱.
  • 暴露会导致严重的神经损伤,需要可靠的监测方法.

研究的目的:

  • 调查神经刺激性测试 (NETs) 对于评估中毒的有用性.
  • 将NET的有效性与传统的电生理学方法进行比较,以反映BLL.

主要方法:

  • 招募了14名暴露于的工人和20名健康对照.
  • 在所有参与者身上进行了神经传导研究 (NCS),通过跨磁刺激 (TMS) 进行了运动唤起潜力 (MEP) 和NET.

主要成果:

  • 在NCS中,工人发现延长的延迟时间和神经传导速度下降,但没有强烈的BLL相关性.
  • 工人表现出明显延长的MEP延迟时间.
  • NETs表明工人的神经过极化,与通道干扰有关,并且与BLL的相关性更强.

结论:

  • 通过NETs检测到的轴突过极化和中央导电延迟,比NCS更好地反映了BLL的升高.
  • 网络显示出早期检测诱导的神经病变的潜力.