较高的血中白素-6水平与耐药结核病的肺腔化有关
Thando Glory Maseko1,2, Slindile Ngubane1, Marothi Letsoalo1
1Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
BMC immunology
|August 31, 2023
概括
高水平的干白素-6增加了耐药结核病 (TB) 肺腔位的风险. 这一发现突出显示了Interleukin-6的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 肺部腔化是结核病 (TB) 传播和治疗结果的关键因素.
- 了解耐药结核病 (DR-TB) 肺部空心的驱动因素对于改善患者管理至关重要.
- 系统性炎症,特别是细胞因子概况在DR-TB腔内疾病中的作用需要进一步阐明.
研究的目的:
- 调查血细胞因子和化学因子水平与耐药结核病患者的肺腔位之间的关联.
- 探索艾滋病毒同时感染对这种关联的影响.
- 为了确定特定的炎症标志物,预测DR-TB中肺部空洞化.
主要方法:
- 在治疗前,分析了来自CAPRISA 020研究 (个性化M(X) DR-TB治疗策略研究) 的128名参与者的血样本.
- 对所有参与者来说,肺腔位的状态都被确定.
- 血细胞因子和化学因子水平使用27-Plex人类细胞因子免疫试验量化,并使用修改后的Poisson回归模型评估与洞穴的关联.
主要成果:
- 升高的IL-6血水平与增加的肺化风险显著相关 (aRR 1.405,p=0.011).
- 吸烟也与更高的肺腔位风险相关 (aRR为1.784,p=0.008).
- 相反,艾滋病毒阳性状态 (aRR 0.537,p=0.001) 和较高的体重指数 (aRR 0.927,p=0.012) 与空洞化风险降低有关.
结论:
- 高血水平的互白素-6是药物耐药结核病肺部空洞化的重要危险因素.
- 这些发现强调了IL-6在洞腔DR-TB的免疫病理学中的关键作用.
- 对IL-6的作用的进一步研究可能为管理腔腔DR-TB提供新的治疗点.
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