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通过分泌有效的中和抗体来对抗SARS-CoV-2的欧米克朗变体,工程化临床级别的介质层细胞进行了抗击

Yanning Wang¹, Tianyun Gao¹, WanTing Li²

¹Clinical Stem Cell Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, 210000, China.

Cell & bioscience

|August 31, 2023

概括

工程化介质层细胞 (MSCs) 创建了一个细胞工厂,不断生产SARS-CoV-2中和抗体,为脆弱的COVID-19患者提供一种新的治疗方法.

科学领域:

生物技术是生物技术.
免疫学免疫学免疫学
细胞疗法细胞疗法

背景情况:

对于老年人和免疫力低下的人来说,SARS-CoV-2 构成了严重的威胁,治疗选择有限.
介酶体 stromal 细胞 (MSCs) 在治疗SARS-CoV-2和减轻其长期影响方面表现有前途.

研究的目的:

开发一种使用临床级MSC的自主细胞机器,用于持续的体内分泌中和抗体来对抗SARS-CoV-2.
评估工程MSCs对抗SARS-CoV-2感染的治疗潜力,特别是在高风险人群中.

主要方法:

在临床级的MSC中构建和转化重组等离子体,以表达中和抗SARS-CoV-2抗体.
使用伪病毒中和试验对稳定的MSC克隆分泌抗体进行查.
在体内研究由工程MSCs分泌的抗体的药理动力学和生物分布.

主要成果:

稳定的临床级MSC克隆表达中和抗体 (XGv347-10和LY-CoV1404-5) 证明了对SARS-CoV-2的可行性和保护效果.
工程MSCs成功地将抗体输送到肺部.
MSC克隆通过抑制CD4+T细胞分化到Th1和Th17亚群来调节COVID-19诱导的免疫超响应.

结论:

设计的临床级MSCs作为有效的细胞工厂,分泌中和抗体,呈现出对SARS-CoV-2的有希望的战略.
这种方法为治疗老年人和免疫力低下的COVID-19患者提供了新的治疗途径.

关键词:

抗SARS-CoV-2 抗体的抗体在 COVID-19 疫情中,基因修饰是一种基因修饰.在MSC中,MSC是MSC.mAbs的交付平台是什么

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...