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甲基酸盐通过抑制MAPK信号通路来保护小鼠免受硫酸诱导的大肠炎的影响

Lilin E¹, Wenjie Li², Yuanjia Hu³

¹Department of Biochemistry and Molecular Biology, Sun Yat-sen University Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Acta biochimica et biophysica Sinica

|September 1, 2023

概括

甲基肉酸 (MC) 通过减少炎症和改善肠道微生物群,有效治疗结肠炎. 这种天然化合物为结肠炎患者提供了一个有希望的,无毒的治疗选择.

科学领域:

药理学药理学是指药理学的学科.
胃肠病学胃肠病学
自然产品化学化学

背景情况:

对大肠炎的有效和无毒的治疗药物很少.
甲基肉酸 (MC) 是从 (Alpinia officinarum) 中提取的,具有抗炎性质.

研究的目的:

为了研究MC在硫酸 (DSS) 诱导的大肠炎中的治疗潜力.
阐明MC抗结肠炎作用的潜在机制.

主要方法:

在小鼠中的DSS诱导性结肠炎模型.
对临床症状,结肠长度和肠道屏障完整性的评估.
在体外和体内对促炎性细胞因子和MAPK信号通路的分析.
用于肠道微生物群分析的16S rRNA测序.

主要成果:

治疗MC缓解了结肠炎症状,包括体重减轻和疾病活动,没有毒性.
MC保护了肠道屏障的完整性,并减少了促炎性细胞因子的表达.
在结肠组织和细胞中,MC抑制了MAPK信号通路 (p38,JNK,ERK).
在大肠炎小鼠中,MC治疗改善了肠道微生物失调.

结论:

甲基肉酸证明了对DSS诱导的大肠炎的显著治疗疗效.
MC通过抑制MAPK信号通路和调节肠道微生物群来起作用.
MC代表了一种潜在的新型,非有毒的治疗候选人,用于结肠炎治疗.

关键词:

在 MAPK 信号通道中.德克斯酸硫酸盐是什么意思炎症性肠病是一种炎症性肠病.甲基胺酸甲基胺酸

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MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...