阿德罗宾通过PPARγ酸化相关的巨细胞极化减轻胰腺炎相关的肺损伤
Fadian Ding1, Guozhong Liu1, Feng Gao2
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
International journal of molecular medicine
|September 1, 2023
概括
调节免疫代谢的蛋白质阿德罗宾在急性胰腺炎 (AP) 中被发现是减少的. 补充阿德罗可以通过促进M2巨细胞极化和调节PPARγ来降低肺损伤的严重程度,为AP相关的肺损伤提供了潜在的治疗标.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢调节 代谢调节 代谢调节
- 肺部医学 肺部医学
背景情况:
- 急性胰腺炎 (AP) 可能导致严重的肺部并发症,称为AP相关的肺损伤 (ALI).
- 阿德罗是一种参与免疫代谢的蛋白质,但其在AP-ALI中的作用尚不清楚.
- 了解阿德罗的功能可能会为AP-ALI揭示新的治疗策略.
研究的目的:
- 调查阿德罗宾对AP相关肺损伤 (AP-ALI) 的免疫调节作用.
- 探索阿德罗宾在AP-ALI中影响巨细胞极化和肺组织损伤的机制.
主要方法:
- 使用ELISA测量了AP患者的血清阿德罗宾水平.
- 使用了AP和adropin淘汰赛 (Adro-KO) 的动物模型.
- 肺组织分析包括组织学,免疫组织化学,免疫光学,西部斑点和RT-qPCR,以评估纤维化,亡和巨分化 (M1/M2).
主要成果:
- 在AP患者和模型中,阿德罗宾表达显著下降.
- 氨酸缺乏症 (Adro-KO) 会加剧肺损伤,增加巨细胞透,纤维化和亡.
- 外源性阿德罗补充剂减轻了肺损伤,促进了M2巨细胞的两极分化,并通过调节其酸化来调节过氧体增殖器激活受体γ (PPARγ) 表达.
结论:
- 阿德罗在AP-ALI中起着保护作用.
- 阿德罗通过促进M2巨细胞两极分化和减少肺组织损伤来发挥其保护作用.
- 该机制涉及PPARγ酸化的调节,这表明阿德罗宾是AP-ALI的潜在治疗点.
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