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在患有失脂症的患者中,Daeshiho-tang降低了LDL胆固醇的影响:试点随机,双盲,安慰剂控制的试验

Ji-Won Noh¹, Byung-Cheol Lee¹

¹Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

|September 1, 2023

概括

这项研究发现,Daeshiho-tang (DSHT),一种草药配方,在8周的时间内,在患有脱脂症的患者中显著降低低密度脂蛋白胆固醇 (LDL-C) 和总胆固醇 (TC). DSHT表现出良好的安全性,没有观察到严重的不良事件.

科学领域:

心血管医学心血管医学
药理学药理学是指药理学的学科.
草药研究草药研究

背景情况:

失脂症是动脉样硬化心血管疾病的主要危险因素.
降低低密度脂蛋白胆固醇 (LDL-C) 对于预防心血管事件至关重要.
大西霍唐 (DSHT) 已显示出临床前改善脂质的效果,但临床证据有限.

研究的目的:

为了评估DSHT在患有脱脂症的患者中降脂功效.
在这个患者群体中评估DSHT的安全性和耐受性.
提供关于DSHT的初步临床数据,用于治疗失脂症.

主要方法:

进行了一项随机,双盲,安慰剂控制的试验.
60名未经治疗的脂质失调症患者接受了DSHT提取物 (3g,每天三次) 或安慰剂8周.
血清脂质概况 (LDL-C,HDL-C,TC,TG) 和阿波脂蛋白水平 (apoA1,apoB) 在基线,4周和8周被测量.

主要成果:

与安慰剂相比,DSHT显著降低了LDL-C14.0 mg/dL (p < 0.01) 和TC13.7 mg/dL (p < 0.01).与安慰剂相比,DSHT显著降低了LDL-C14.0 mg/dL (p < 0.01) 和TC13.7 mg/dL (p < 0.01).
在DSHT组 (7.03 mg/dL,p <0.05) 观察到阿波利波蛋白-B (apoB) 的显著降低.
在这两组中,安全生化标记 (AST,ALT,GGT,肌素,eGFR) 没有显著变化.

结论:

在患有脱脂症的患者中,DSHT有效地改善了脂质配置文件,特别是降低了LDL-C和apoB水平.
在8周的治疗期间,草药配方DSHT是安全的,并且能很好地容忍.
这项研究支持DSHT作为一种潜在的治疗选择来治疗失脂症.

关键词:

在阿波利波蛋白B.达西霍 - 唐 (Daeshiho - 唐) 是一个城市.脱脂血症是什么意思脱脂血症是什么意思草药是一种草药.低密度脂蛋白胆固醇是低密度的脂蛋白胆固醇.

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