在极低妊娠年龄的新生儿中,在过渡期内大脑氧化,心脏输出和血压之间的关系
Poorva Deshpande1,2, Caio Barbosa de Olivera1,2, Amish Jain1,2
1Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Frontiers in pediatrics
|September 1, 2023
概括
极低妊娠年龄新生儿 (ELGANs) 在过渡期中显示大脑氧化和血液流动之间存在弱相关性. 需要进一步的研究来证实患有ELGANs的大脑自我调节.
科学领域:
- 新生儿生理学 新生儿生理学
- 大脑血液动力学
- 进行心血管监测.
背景情况:
- 极低妊娠年龄新生儿 (ELGANs) 在从胎儿到新生儿生活的过渡期间经历了显著的生理变化.
- 维持足够的大脑氧化和血液流动对于ELGANs的神经发育结果至关重要.
- 了解全身血动力学和大脑循环之间的相互作用对于优化护理至关重要.
研究的目的:
- 在新生儿早期的ELGAN中调查大脑氧化和大脑血流速度之间的关系.
- 探索心脏输出,动脉血压和大脑氧化参数之间的相关性.
- 评估与血液动力学变量相关的大脑部分组织氧气提取 (CFTOE).
主要方法:
- 一项涉及ELGANs的前性观察研究的二次分析.
- 在出生后72小时内进行脑和 (CrSO2) 监测和串行心声扫描.
- 在CrSO2,CFTOE,心室输出 (LVO,RVO),SVC流量,中脑动脉平均速度 (MCA.MV) 和血压 (SBP,DBP,MBP) 之间进行了相关分析.
主要成果:
- 分析了50个ELGAN (妊娠年龄为23.1-27.9周).
- 随着时间的推移,右心室和左心室输出,CrSO2和静脉压增加.
- 17.3小时发现CrSO2和SBP/MBP之间存在微弱的相关性;CrSO2/CFTOE和血液流量测量之间没有显著的相关性.
结论:
- 心脏输出,血压和中脑动脉平均速度与过渡期间ELGAN中脑氧化之间存在微弱的相关性.
- 需要对一组患病的ELGAN进行进一步的前性评估,以确定这些发现是否表明完整的脑自调节.
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