在OSCC和正常印度患者中唾液维生素D水平
Sandra Sagar1, Pratibha Raman1, S Gheena1
1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, India.
Bioinformation
|September 1, 2023
概括
口腔状细胞癌患者的唾液维生素D3水平明显低于健康人群. 这表明维生素D缺乏可能会恶化口腔癌的进展,突出显示补充剂的潜在益处.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 口腔状细胞癌 (OSCC) 占口腔癌的90%以上.
- 越来越多的人认为维生素D水平是影响癌症治疗结果的因素.
- 唾液提供了一个非侵入性的生物标志物,用于评估系统性健康指标,如维生素D.
研究的目的:
- 为了评估和比较被诊断患有OSCC的患者的唾液维生素D3水平,与健康的对照人群相比.
- 调查维生素D水平作为OSCC生物标志物的潜在作用.
主要方法:
- 招募了40名参与者 (20名OSCC患者,20名健康对照) 的队列.
- 从所有参与者身上收集了唾液样本.
- 使用维生素D3ELISA套件 (EDI总25-OH维生素DEIA套件) 量化了唾液维生素D3水平.
主要成果:
- 与健康对照组 (44.49 ng/dl) 相比,OSCC患者的平均唾液维生素D3水平较低 (39.09 ng/dl).
- 在OSCC组和对照组之间的唾液维生素D3水平的差异在统计学上是显著的.
- 在OSCC患者中维生素D3水平较低表明与癌细胞增多,入侵和转移的潜在关联.
结论:
- 在患有口腔状细胞癌的患者中,观察到唾液维生素D3水平显著降低.
- 维生素D缺乏可能与更具侵略性的OSCC进展有关.
- 维生素D补充可能会改善预后,并在治疗期间和治疗后减少OSCC患者的疾病严重程度.
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