液体活检在瘤学的进展和应用:叙述性审查
Jawad Noor1, Ahtshamullah Chaudhry1, Riwad Noor2
1Internal Medicine, St. Dominic Hospital, Jackson, USA.
Cureus
|September 1, 2023
概括
液体活检提供了一种不那么侵入性的方法来监测癌症动态,并指导个性化治疗. 这些先进的诊断工具分析循环的瘤DNA和细胞,以更好地治疗癌症.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 癌症研究 癌症研究
背景情况:
- 癌症是全球死亡的主要原因,需要创新的诊断方法.
- 传统的组织活检在监测动态瘤变化方面存在局限性.
- 液体活检已经成为癌症检测和管理的有希望的非侵入性替代方案.
研究的目的:
- 审查液体活检技术的最新进展.
- 探索液体活检在瘤学中的应用和局限性.
- 讨论液体活检在改变癌症诊断,预后和治疗方面的潜力.
主要方法:
- 对循环瘤DNA (ctDNA) 的分析.
- 检测循环的瘤细胞 (CTC).
- 对细胞外囊泡和微RNA的评估.
- 审查关于液体活检技术和应用的当前文献.
主要成果:
- 液体活检提供实时,非侵入性监测瘤动态.
- 它们提供了关于瘤异质性,治疗反应和最小残留疾病的见解.
- 优点包括比组织活检更少侵入性,更方便,更能代表瘤异质性.
结论:
- 液体活检在临床瘤学中越来越多地被使用,特别是在转移性疾病中.
- 这些技术具有重大潜力,可以彻底改变癌症诊断,预后和个性化治疗策略.
- 进一步开发和验证对于广泛的临床采用至关重要.
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