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孕产妇丸激素水平升高会改变孕妇大鼠的PFOA消除和组织分布

Pankaj Yadav¹, Jay S Mishra¹, Sathish Kumar^1,2,3

¹Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.

Journal of environmental science and public health

|September 1, 2023

概括

在怀孕的老鼠中,丸激素的升高降低了有害化学物质 perfluorooctanoic acid (PFOA) 的排泄. 这种荷尔蒙变化导致母体组织中PFOA度更高,引发了健康问题.

科学领域:

环境毒理学环境毒理学
生殖毒理学生殖毒理学
内分泌学在内分泌学.

背景情况:

perfluorooctanoic 酸 (PFOA) 是一种持久性合成化学物质,具有已知的人类健康风险.
在孕妇患有先兆子症时,PFOA的生物积累明显高于孕妇.
孕前与血中丸激素水平升高有关.

研究的目的:

调查怀孕期间的高雄激素状况是否会影响PFOA的排泄.
为了确定丸激素升高对PFOA对身体负担和妊娠大鼠组织分布的影响.

主要方法:

怀孕的斯普拉格-道利大鼠被给予 propionate,以模仿产前的荷尔蒙水平.
[14C]-PFOA是在妊娠16日静脉注射的.
在母亲的血液,尿液,便和组织中测量了放射性,以评估PFOA的消除和分布.

主要成果:

与对照人群相比,较高的丸激素显著减少了12%的尿路PFOA分泌.
在接受丸激素治疗的组中,PFOA的总排泄 (尿 + 便) 减少.
在孕妇大鼠中,PFOA的组织度在孕妇大鼠中高出12%,而这些大鼠的丸激素水平较高.
运输基因表达 (Oat2,Oat3,Oatp1,Oat-k) 被改变,以应对的升高.

结论:

母体丸激素水平升高会阻碍PFOA在怀孕期间通过尿液排出.
改变运输体表达可能导致PFOA分泌量下降.
这些发现表明,在高雄性妊娠中,PFOA体负荷增加的机制存在.

关键词:

生物积累生物积累生物积累脏 - 脏 - 脏 perfluorooctanoic 酸的含量是多少在怀孕的老鼠身上.测试激素测试激素是什么运输商运输商运输商

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