长非编码RNA在癌症中的作用:从亚细胞局部化到纳米粒子介导的向调节
Chunfang Wei1,2, Ya Xu1,2, Qian Shen3
1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Molecular therapy. Nucleic acids
|September 1, 2023
概括
长非编码RNAs (lncRNAs) 是癌症的关键. 纳米粒子传递系统正在出现,用于针对性调节lncRNA表达和新型癌症疗法.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 生物技术是生物技术.
背景情况:
- 长非编码RNAs (lncRNAs) 是癌症发展和进展的关键调节者.
- 它们的亚细胞局部影响生物功能和调节机制.
- lncRNAs越来越多地被认为是瘤学中的生物标志物和治疗点.
研究的目的:
- 审查功能性 lncRNAs 在癌症中的亚细胞局部化和调节机制.
- 总结纳米粒子 (NP) 介导的核酸输送系统在 lncRNA 调节方面的进展.
- 突出这些系统在向癌症治疗中的潜力.
主要方法:
- 文献综述侧重于lncRNA功能,本地化和基于NP的传递系统.
- 对纳米粒子介导核酸输送用于癌症治疗的当前研究进行分析.
- 综合有关lncRNA调节作用和治疗向的信息.
主要成果:
- lncRNAs在癌症中扮演着不同的角色,其位置决定了功能.
- 基于纳米粒子的传递系统显示出对精确的 lncRNA 表达的 *in vivo* 调节的前景.
- 这些系统通过准 lncRNA驱动的途径,为癌症治疗提供了一种新的策略.
结论:
- 了解 lncRNA 亚细胞局部化对于阐明它们在癌症中的作用至关重要.
- 纳米粒子介导的核酸输送是通过调节lncRNA表达来向癌症治疗的一个有希望的途径.
- 这一领域的进一步研究可能会导致更有效和更具体的癌症治疗方法.
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