克罗恩病排除饮食对缓解的影响:系统性审查
Zhanhui Zhu1, Yang Lei2, Zheng Lin2,3
1School of Nursing, Nanjing Medical University, Nanjing, China.
Therapeutic advances in gastroenterology
|September 1, 2023
概括
克罗恩病排除饮食 (CDED) 在帮助儿童和成年人实现轻度至中度克罗恩病缓解方面表现有前途. 需要进一步的研究来证实这些关于饮食治疗有效性的发现.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 炎症性肠道疾病是什么
背景情况:
- 与医疗治疗相比,饮食疗法提供了一种潜在的更安全,更具成本效益的方法来管理克罗恩病.
- 克罗恩氏病排除饮食 (CDED) 是一种有针对性的饮食干预措施,旨在最大限度地减少对可能加剧克罗恩氏病患者肠道炎症的特定食物成分的暴露.
研究的目的:
- 系统地审查有关克罗恩病排除饮食 (CDED) 治疗克罗恩病的有效性的现有文献.
主要方法:
- 在多个主要的科学数据库 (PubMed,EBSCOhost,Cochrane图书馆,OVID,Embase,Scopus,CINHAL) 进行了全面的系统搜索.
- 确定并分析了2014年1月1日至2022年8月31日期间发表的相关临床试验.
- 七项研究符合纳入标准,该审查遵守了系统性审查和元分析 (PRISMA) 首选报告项目指南.
主要成果:
- 该分析包括了最初识别的1120项研究中的7项研究.
- 克罗恩病排除饮食 (CDED) 在诱导和维持轻度至中度克罗恩病的儿科和成人患者的缓解方面表现出潜在的有效性.
结论:
- 克罗恩病排除饮食 (CDED) 似乎是管理轻度至中度克罗恩病的可行选择,在缓解诱导和维持缓解方面表现出有效性.
- 在包含的研究中发现了显著的异质性和局限性.
- 建议进行高质量的随机临床试验,以进一步验证CDED的有效性.
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