新诊断出患有异常葡萄糖耐受症的年轻患者的血清同类半氨酸水平
Amrit Rijal1, Nusrat Sultana1, Mashfiqul Hasan1
1Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh.
SAGE open medicine
|September 1, 2023
概括
患有糖尿病的年轻人与正常葡萄糖耐受性患者相比,血清类固醇水平较低. 这一发现突显了同类氨酸,葡萄糖耐受性和年轻人心血管风险之间的联系.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 超homocysteinemia是早期心血管事件的新兴风险因素.
- 在患有葡萄糖不耐受症的年轻人中了解同型半氨酸水平对于评估心血管风险至关重要.
研究的目的:
- 为了评估新诊断的年轻人 (年龄<30岁) 血清同类半氨酸水平,具有异常的葡萄糖耐受性.
- 为了在不同的血糖状况谱中比较同型半氨酸水平:正常的葡萄糖耐受性,糖尿病前期和糖尿病.
主要方法:
- 一项横截面研究包括80名年轻参与者 (40名葡萄糖耐受性异常,40名葡萄糖耐受性正常).
- 用美国糖尿病协会2021年标准来确定血糖状况.
- 使用化学发光免疫测试测量血清同型半氨酸.
主要成果:
- 在血糖状况组中,同类半氨酸水平有显著差异 (p=0.006).
- 与糖尿病相比,血清同型半氨酸在正常葡萄糖耐受性上显著升高 (p=0.006).
- 在47.5%的正常葡萄糖耐受性参与者和22.5%的异常葡萄糖耐受性 (p=0.019) 参与者中观察到高水平的同型半氨酸.
结论:
- 患有糖尿病的年轻患者 (<30岁) 呈现出比正常葡萄糖耐受度较低的同类氨酸水平.
- 这些发现表明,在年轻人群体中,同类氨酸,血糖状况和心血管风险之间存在复杂的关系.
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