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Updated: Jul 17, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

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(II) 复合体对粉样蛋白聚合的抑制作用:一种理论和实验方法

Sara La Manna1, Valentina Roviello2, Vittoria Monaco3,4

  • 1Department of Pharmacy, University of Naples Federico II, 80131, Naples, Italy. daniela.marasco@unina.it.

Dalton transactions (Cambridge, England : 2003)
|September 1, 2023
PubMed
概括

(II) 复合物,如甲,通过在与神经退行性疾病相关的模型中有效抑制粉样蛋白聚合,显示出作为神经治疗药物的潜力.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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EDTA: Auxiliary Complexing Reagents01:26

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EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
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