从Illicium ternstroemioides的根源中取出的化C6 - C3衍生物具有抗病毒活性
Jia Yang1, Wen-Rui Li1, Qian-Ru Wang1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Journal of Asian natural products research
|September 1, 2023
概括
从Illicium ternstroemioides根中分离出六种新的前化C6-C3化合物. 化合物5对Coxsackievirus B3表现出强大的抗病毒活性,表明潜在的治疗应用.
科学领域:
- 自然产品化学 自然产品化学
- 有机化学 有机化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 伊利 (Illicium ternstroemioides) A. C. 史密斯的根是一种多种化学化合物的来源.
- 化C6-C3衍生物代表了一类具有潜在生物活性的天然产品.
研究的目的:
- 从*Illicium ternstroemioides*根中分离和鉴定新型的化C6-C3衍生物.
- 评估隔离化合物的抗病毒活性,以对抗Coxsackievirus B3.
主要方法:
- 使用色谱技术分离化合物.
- 通过广泛的光谱分析阐明结构,包括UV,IR,1D和2DNMR,以及HRESIMS.
- 使用电子圆二元制 (ECD) 和Mo2(OAc) 4诱导圆二元制 (ICD) 确定绝对配置.
主要成果:
- 六个以前未被描述的先化C6-C3衍生物,化合物1-6被成功分离出来.
- 化合物1-3的结构和绝对配置被严格确定.
- 化合物3对Coxsackievirus B3的活性较弱 (IC50 = 33.3μM),而化合物5则表现出更强烈的活性 (IC50 = 6.4μM).
结论:
- 这项研究成功地发现了来自Illicium ternstroemioides*的新型前化C6-C3化合物.
- 化合物5显示出作为对Coxsackievirus B3的抗病毒剂的显著潜力,需要进一步调查.
相关概念视频
Subviral Agents
41
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
41
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
205
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
205
Antimicrobial Effectiveness
44
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
44


