中期剂量间隔度对于重症患者的多素B暴露和急性损伤很重要
Jing Wang1, Yuanchen Li2, Siqi Huang3
1Department of Pharmacy, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
CPT: pharmacometrics & systems pharmacology
|September 1, 2023
概括
白细胞计数和聚素B (PMB) 暴露,以度-时间曲线 (AUC) 下的面积来衡量,是重症患者急性损伤 (AKI) 的关键风险因素. 治疗药物监测可以指导PMB剂量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临界护理医学 临界护理医学
背景情况:
- 聚米辛B (PMB) 对于治疗多药耐药的格拉姆阴性感染至关重要.
- 急性损伤 (AKI) 是与PMB治疗相关的重大并发症.
- 确定PMB诱导的AKI的风险因素对于患者安全至关重要.
研究的目的:
- 在重症患者中调查PMB暴露和AKI之间的关联.
- 确定有助于PMB诱导的AKI的独立风险因素.
- 为了建立AKI风险的预测值.
主要方法:
- 血PMB度的测量使用超高性能液体染色学-并联质谱法.
- 单变量和多变量分析确定了AKI的风险因素.
- 接收器操作特征 (ROC) 曲线分析确定了预测功率和切断值.
主要成果:
- 白细胞计数和PMB度-时间曲线 (AUC) 下的估计面积是AKI的独立风险因素.
- 最终的预测模型实现了ROC曲线下的面积为0.805.5.
- 一个C1/2t的3.47μg/ml的值显示了AKI风险的有利差异化.
结论:
- 白细胞计数和PMB AUC是重症患者AKI的重要预测指标.
- 治疗药物监测PMB,特别是C1/2t,可以帮助优化剂量和减轻AKI风险.
- 这些发现支持PMB治疗药物监测的临床实施,以改善患者的治疗结果.
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