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奇托:一种绿色粘合剂,用于表面功能化和制造热塑生物医疗微设备
Kieu The Loan Trinh1, Duc Anh Thai2, Da Hyun Yang2
1BioNano Applications Research Center, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, Korea.
Lab on a chip
|September 1, 2023
概括
酸盐 (CS) 能够在使用氧等离子体的条件下使聚甲基酸盐 (PMMA) 微器件在室温下强烈结合. 这种具有成本效益的方法制造了用于干细胞培养和照顾点DNA测试的设备.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 微流体学 微流体学
背景情况:
- 酸盐 (CS) 是一种多功能天然聚合物,在生物材料中具有应用.
- 之前的研究使用了CS-多利多巴胺来进行PMMA微设备的紫外线辅助结合.
- 为微型设备开发强大的室温制造方法至关重要.
研究的目的:
- 使用CS和氧等离子体,在室温下实现PMMA基板的可靠粘合.
- 为了证明用于直接微设备应用的同时粘合剂粘合和表面功能化.
- 为了验证用于干细胞培养和临床检测 (POCT) 应用的制造微设备.
主要方法:
- 在室温下使用奇托和氧等离子体对PMMA基质进行粘合.
- 使用接触角度,FTIR,SEM和AFM进行表面表征.
- 微设备的制造用于介质干细胞培养和在芯片上的DNA净化用于POCT.
主要成果:
- 实现了PMMA的可靠粘合,粘合强度为2.1 MPa,稳定超过两个月.
- 同时完成了微通道的粘合粘合和表面功能化.
- 在介质干细胞球形生成和用于检测病原性细菌的DNA净化中成功应用.
结论:
- 用CS辅助的氧等离子处理为PMMA微器件制造提供了方便和可靠的策略.
- 该方法可以在没有先前表面修改的情况下直接应用于生物研究和POCT设备.
- 这种方法促进了诸如干细胞培养和快速病原体检测等先进应用.
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