周围前列腺静脉激素升高与激进前列腺切除术后前列腺癌进展相关
Mohammad Alyamani1, Patrick Michael1,2, Daniel Hettel1,2
1Genitourinary Malignancies Research Center, Lerner Research Institute.
The Journal of clinical investigation
|September 1, 2023
概括
前列腺区域局部丸激素 (T) 水平较高的男性在前列腺癌手术后的结果较差. 这表明局部T暴露会影响前列腺癌的进展.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 淋巴体 (T) 的临床评估通常依赖于周围血液水平.
- 前列腺T暴露被认为是镜像的外围水平,尽管雄激素驱动前列腺癌.
- 周围T尚未在临床上用于局部前列腺癌的评估或治疗.
研究的目的:
- 调查局部雄激素输送在前列腺癌中的作用.
- 为了将背静脉丸激素 (DT) 水平与周围血液 (PT) 和前列腺组织T度进行比较.
- 评估DT/PT比率与前列腺切除术后无进展生存率之间的关联.
主要方法:
- 从266名经过激进前列腺切除术的男性的前列腺背静脉综合体中采集了血液样本.
- 进行了全面的向类固醇和代谢学分析.
- 评估了DT/PT比率与无进展生存时间之间的关联.
主要成果:
- 与PT水平相比,一些男性的DT水平显著增加 (在20%的男性中高出2倍).
- 在背部静脉中富含异甲酸和17-OH-孕表明丸转移.
- 提升的DT水平与更高的前列腺癌复发率相关,并预测了更糟糕的结果.
结论:
- 显著比例的男性经历了缩的前列腺丸激素的不被赞赏,未经稀释的暴露.
- 周围前列腺T暴露的增加与急性前列腺切除术后的不良临床结果有关.
- 这些发现突显了局部T测量在前列腺癌管理中的临床相关性.
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