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-乙糖胺及其二聚物通过加强肠道屏障功能来改善小鼠结肠炎的炎症

Sung-In Choi¹, Young Chul Shin², Joong Su Lee²

¹Department of Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Chungpa-ro 47-gil 100, Yongsan-gu, Seoul 04310, Republic of Korea. mksung@sookmyung.ac.kr.

Food & function

|September 1, 2023

概括

在治疗性结肠炎方面,N-乙糖胺 (NAG) 和其二元 (NAG-D) 是有前途的. 补充改善了肠道屏障功能,减少了炎症,并在小鼠模型中恢复了微生物平衡.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,其全球发病率正在增加.
目前的治疗方法,如5-氨基酸,皮质类固醇和免疫抑制剂都有局限性和副作用.
一种氨基糖N-乙糖胺 (NAG) 在粘素生产和肠道细菌生长中起作用.

研究的目的:

评估N-乙糖胺 (NAG) 和其二元 (NAG-D) 在硫酸 (DSS) 诱导的慢性结肠炎小鼠模型中的疗效.
阐明NAG和NAG-D在缓解大肠炎中的潜在作用机制.

主要方法:

通过使用DSS诱导慢性结肠炎的小鼠,并用硫沙拉,NAG或NAG-D治疗.
评估的参数包括体重,疾病活动指数,结肠组织损伤,结肠长度,粘素分泌,肠透性 (血清CD14),紧结蛋白表达 (occludin),炎症生物标志物和肠道微生物群组成.

主要成果:

NAG-D显著改善了结肠炎症状,包括减肥,疾病活动和结肠损伤.
通过改善血清CD14度和奥克卢丁表达,NAG治疗增强了肠道屏障功能.
NAG和NAG-D都减少了关键的炎症生物标志物和调节了肠道微生物群,降低了致病细菌的比例.

结论:

补充N-乙糖胺 (NAG) 和NAG-二聚合物 (NAG-D) 有效地缓解了小鼠的DSS诱导的大肠炎.
治疗效果归因于强化肠道屏障功能和恢复肠道微生物群平衡.
NAG和NAG-D代表了性结肠炎管理的潜在治疗替代方案.

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