正静性低血压和正静性高血压都与较低的认知功能有关:S.AGES队列
M Strumia1,2, J S Vidal3,4, P Cestac1,2
1Maintain Aging Research Team, CERPOP, Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France.
Journal of the American Geriatrics Society
|September 1, 2023
概括
正静性低血压 (OHYPO) 和正静性高血压 (OHYPER) 与老年人的认知功能下降有关. 在站立时监测血压变化可能有助于识别有认知能力下降风险的个体.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 神经科学是一个神经科学.
背景情况:
- 姿势血压变化,包括静止性低血压 (OHYPO) 和静止性高血压 (OHYPER),在老年人中很普遍.
- 有限的研究已经探索了这些血压异常和认知功能之间的联系,特别是OHYPER,一个新兴的心血管风险因素.
研究的目的:
- 调查OHYPO,OHYPER和非机构老年人的认知表现之间的关联.
主要方法:
- 在S.AGES队列研究中,65岁及以上没有痴呆症的非机构受试者被跟踪了3年.
- OHYPO和OHYPER被定义为站立时特定的缩和/或腹缩血压变化.
- 认知功能使用微型心理状态检查 (MMSE) 进行评估,分析采用线性混合模型.
主要成果:
- 在3170名参与者中,6.5%的人在基线有OHYPO,7.1%的人有OHYPER.
- 经过调整后,OHYPER的参与者显示平均MMSE低0.52点 (p=0.02),OHYPO的参与者显示平均MMSE低0.50点 (p=0.03),与正常血压姿势变化的人相比.
- 敏感性分析表明OHYPO和认知功能之间存在剂量反应关系.
结论:
- OHYPO和OHYPER都与老年人的认知功能下降有关,尽管MMSE得分的绝对差异很小.
- 静态血压测量可以帮助识别有认知障碍风险的个体.
- 需要进行进一步的研究,以确定管理静态血压是否是保持老年人认知健康的可行策略.
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