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作为肠道炎症标志物的便calprotectin在玻璃眼中升高

Zuo Wang¹, Hang Yuan², Xiong Zhu³

¹Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China.

Biomarkers in medicine

|September 1, 2023

概括

玻璃眼患者表现出便中calprotectin水平升高,这表明潜在的肠道炎症. 这一发现将眼睛疾病与肠道健康标志物联系在一起.

科学领域:

眼科医生眼科眼科
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
肠道炎症与各种系统性疾病有关.
便中的calprotectin是肠道炎症的敏感标记物.

研究的目的:

为了研究青光眼和便中calprotectin水平之间的关联.
为了确定便calprotectin是否在患有玻璃眼的患者中升高.
为了探索眼和肠道炎症之间的潜在联系.

主要方法:

与酶相关的免疫吸收试验 (ELISA) 用于测量便中的calprotectin.
包括144名患有青光眼的患者和66名健康对照.
玻璃眼被分为主要的闭角玻璃眼和主要的开角玻璃眼.

主要成果:

与对照组相比,青光眼患者的便calprotectin水平的中位数明显高于对照组 (73.67比41.97μg/g,p<0.001).
在初级闭角眼 (76.85 μg/g,p < 0.001) 和初级开角眼 (69.29 μg/g,p = 0.016) 分组中观察到便calprotectin的升高.
显著比例的青光眼患者 (21-24%) 呈现出高度异常的便calprotectin水平 (≥250μg/g).

结论:

青光眼患者便中calprotectin水平升高表明潜在的潜在肠道炎症.
便中的calprotectin可以作为与玻璃眼相关的全身炎症的生物标志物.
需要进一步的研究来阐明肠道健康和青光眼病原体之间的关系.

关键词:

这就是 PACG PACG 的意思.波阿格 (POAG) 是一个生物标志物生物标志物便中的calprotectin是一种便的calprotectin.玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼肠道炎症是一种肠道炎症.

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