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Updated: Jul 17, 2025

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons
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Published on: November 20, 2012

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Shank3的Shank/ProSAP N-Terminal (SPN) 域调节了针对 postsynaptic 站点和 postsynaptic 信号的准

Daniel Woike1, Debora Tibbe1, Fatemeh Hassani Nia1

  • 1Institute for Human Genetics, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Molecular neurobiology
|September 1, 2023
PubMed
概括

在Shank蛋白中的Shank/ProSAP N-终端 (SPN) 和Ankyrin (Ank) 域调节了突触后信号传递和蛋白质定位. 这种SPN-Ank模块对于适当的突触功能至关重要,并可能解释自闭症相关变异如何影响Shank3.

关键词:
自闭症谱系障碍 自闭症谱系障碍状棘是一种状棘.地图酶信号传递后突触密度是指突触后的密度.小型G蛋白是一种小型G蛋白.

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