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术前hs-CRP/HDL比率与老年患者术后SIRS风险增加有关:一项回顾性队列研究
Xiaorui Chen1, Jingjing Chen2, Weiqiang Chen3
1Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.
老年患者手术前高hs-CRP/HDL比率 (CHR) 与术后系统性炎症反应综合征 (SIRS) 的风险增加有关. 这一发现凸显了CHR作为手术老年人不良结果的潜在预测标志物.
科学领域:
- 老年医学 老年医学
- 外科手术的结果
- 炎症标记物 炎症标记物
背景情况:
- 系统性炎症反应综合征 (SIRS) 在老年患者中显著影响术后恢复.
- 确定术后SIRS的预测标志物对于改善这一人口群体的结果至关重要.
研究的目的:
- 调查术前高hs-CRP/HDL比率 (CHR) 与老年患者术后SIRS发展风险之间的关联.
- 评估CHR作为老年人手术群体中术后并发症的潜在预测因素.
主要方法:
- 回顾性队列研究,涉及接受全身麻醉的老年患者 (≥65岁).
- 手术前的CHR被分为两组 (≤12.82和>12.82).
- 针对性最大概率估计用于分析CHR和术后SIRS发病率之间的关系.
主要成果:
- 这项研究包括5595名老年患者;25.20%的患者在术后出现SIRS.
- 术前CHR>12.82与术后SIRS风险增加显著相关 (aOR=1.40).
- 更高的CHR也与增加SIRS流行,住院死亡率,更长的住院时间和更高的医疗费用有关.
结论:
- 术前CHR>12.82是老年患者术后SIRS的重要独立风险因素.
- 术前CHR升高可能作为一种有价值的生物标志物,用于识别患有SIRS风险较高的老年手术患者.
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