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奎尔素通过调节基于血代谢的阿佩林信号通路来减轻动脉样硬化

Li-Qun Liu¹, Peng Zhang², Ying-Zi Qi³

¹The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.

Chinese journal of integrative medicine

|September 1, 2023

概括

奎尔丁治疗通过增强阿佩林信号通路来减少动脉样硬化 (AS). 这种天然化合物改善了ApoE-/-小鼠的大动脉形态和脂质沉积.

科学领域:

药理学药理学是指药理学的学科.
心血管研究研究心血管研究
生物化学生物化学

背景情况:

动脉样硬化 (AS) 是一种慢性炎症性疾病,其特征是脂质沉积和动脉壁加厚.
缺乏阿波利波蛋白E (ApoE-/-) 的小鼠是研究AS的广泛使用的模型,因为它们的动脉样硬化病变的发展.
奎尔塞丁是一种黄类化合物,已显示出潜在的抗炎和抗氧化特性.

研究的目的:

阐明 quercetin 在治疗动脉样硬化的药理学机制.
在AS小鼠模型中调查氨酸对巨细胞透,组织衰老和脂质沉积的影响.
在AS治疗中识别Quercetin针对的特定分子通路.

主要方法:

动脉样硬化被诱导在阿波利波蛋白E缺陷 (ApoE-/-) 的小鼠中,其中一组接受氨酸治疗.
免疫组织化学和免疫光学被用来评估巨细胞标记物 (CD11b,F4/80) 和衰老标记物 (P21).
超高性能液态染色学/双重质谱学 (UPLC-MS/MS) 和西部斑分析被用来研究阿佩林信号通路中的代谢物概况和关键蛋白质表达.

主要成果:

奎尔丁治疗显著减少了脂质沉积,并改善了ApoE-/-小鼠的大动脉形态.
奎尔丁降低了巨细胞透和组织衰老标志物,同时增加了血清阿佩林水平和大动脉APJ和Sirt1表达.
奎尔素通过增加APJ,AMPK,PGC-1α,TPA和UCP1蛋白表达和降低AT1R水平来调节阿佩林信号通路,通过阻断ML221路径来证实这些效应.

结论:

奎尔在小鼠模型中有效地缓解动脉样硬化病变.
奎尔在AS的治疗效果是通过对阿佩林信号通路的上调调节来调节的.
奎尔赛丁通过向阿佩林通路,代表了动脉样硬化的潜在治疗剂.

关键词:

阿佩林信号通道的信号通道.动脉样硬化动脉样硬化血代谢学血代谢学文素 (Quercetin) 是一种文素.

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