用levothyroxine进行过量或过少的治疗
Nersi Alaeddin1, Rutchanna M S Jongejan, Julia C Stingl
1Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Institute of Clinical Pharmacology, Faculty of Medicine, RWTH Aachen, Germany; Academic Centre for Thyroid Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.
许多Levothyroxine使用者经历了低于最佳的治疗,其中22%的治疗过度或过少. 老年人更容易接受过度治疗,这突出了需要仔细调整勒沃西的剂量.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 利沃甲状腺素是广泛用于治疗甲状腺疾病的药物.
- 不适当的治疗,包括过度治疗和治疗不足,是常见的问题.
- 有限的研究存在于影响亚最佳利沃西治疗的因素.
研究的目的:
- 调查levothyroxine治疗不足的患病率和决定因素.
- 在基于人口的研究中分析与levothyroxine剂量相关的因素.
主要方法:
- 基于人口的莱研究2938名参与者的数据分析.
- 后勤回归用于识别过度治疗 (铁热素<0.56 mU/L) 和治疗不足 (铁热素>4.27 mU/L) 的决定因素.
- 使用线性回归来评估勒沃西剂量的决定因素.
主要成果:
- 23%的参与者正在服用勒沃西,其中18%的治疗过度,4%的治疗不足.
- 70岁以上的个人治疗过度的可能性是四倍 (OR = 4.05).
- 较高的勒沃甲状腺素剂量与过度治疗和治疗不足的风险增加有关. 补充与较低的剂量有关,而较长时间使用勒沃西与较高的剂量相关.
结论:
- 莱沃甲状腺素的摄入量很高,但即使有监测,也往往不够理想.
- 这些发现强调了精确的勒沃西剂量的必要性.
- 在某些情况下,考虑降低治疗强度是合理的.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Drug Therapy
Antianxiety Medications


