诊断和治疗腹膜癌的诊断和治疗
Dirk Walter1, Andreas A Schnitzbauer, Falko Schulze
1Department of Internal Medicine, J.W. Goethe University Hospital, Frankfurt/Main; Department of General, Visceral, Transplant- and Thoracic Surgery, J.W. Goethe University Hospital, Frankfurt/Main; Dr. Senckenberg Institute for Pathology, University Hospital Frankfurt, Goethe University Frankfurt am Main.
Deutsches Arzteblatt international
|September 1, 2023
概括
腹膜癌的治疗缺乏统一的建议. 决策应考虑组织学亚型,并由跨学科的瘤委员会做出决定,因为证据不足.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 腹膜癌或腹膜癌起源于主要的十二指卵泡粘膜 (Vater的腹膜).
- 对于辅助和息护理方案,没有统一的治疗指南.
- 这种恶性瘤的发病率很低,但预后不好.
研究的目的:
- 审查囊癌的流行病学,临床病理特征和治疗.
- 确定治疗策略的当前证据.
主要方法:
- 进行了PubMed的选择性文献搜索.
- 确定了专注于流行病学,临床病理背景和治疗的出版物.
主要成果:
- 腹膜癌的5年生存率为41-45% (局部化) 和4-7% (转移性).
- 胰腺胆亚型的预后比肠道亚型更差 (平均存活期为72-80个月,而33-41个月).
- 胰腺头部的彻底瘤切除与淋巴切除术是主要的治疗方法;辅助疗法缺乏建议. 息治疗可能适应结肠,胰腺和胆道癌症的策略.
结论:
- 对囊癌治疗的证据有限.
- 组织学亚型应指导治疗决策.
- 跨学科的瘤委员会讨论对于治疗计划至关重要.
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