约旦1型糖尿病儿童和青少年的相关自身免疫甲状腺疾病
Rasha Odeh1, Lobna Gharaibeh2, Sarah Ibrahim1
1Department of Pediatrics, School of Medicine, University of Jordan, Amman, Jordan.
Journal of pediatric endocrinology & metabolism : JPEM
|September 1, 2023
概括
甲状腺自身免疫在约旦1型糖尿病儿童中很常见,甲状腺功能低下症影响7%的患者. 女性和那些具有谷氨酸脱碳酶抗体的人面临更高的风险.
科学领域:
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 1型糖尿病 (T1D) 是一种自身免疫性疾病.
- 甲状腺自身免疫是T1D患者常见的并发症.
- 了解特定人群中的患病率对于管理至关重要.
研究的目的:
- 为了确定甲状腺自身免疫和相关甲状腺疾病的患病率.
- 确定约旦儿童和青少年患有T1D的这些疾病的危险因素.
主要方法:
- 在约旦大学医院 (2012-2021) 的684名T1D儿童的回顾性分析.
- 测量甲状腺刺激激素,自由T4,抗甲状腺过氧化酶抗体 (TPOAb) 和抗甲状腺球蛋白抗体 (TGAb).
主要成果:
- 在7%的患者中发现甲状腺功能低下症 (亚临床和明显).
- 阳性TPOAb和TGAb分别在22.6%和23.1%的受试者中检测到.
- 女性性别和积极的谷氨酸脱碳酶抗体是甲状腺功能低下的预测因素.
结论:
- 对于约旦儿童和青少年患有T1D,建议对甲状腺自身免疫进行查.
- 应特别注意女性和具有阳性谷氨酸脱酶抗体的女性.
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